Structure of PDB 2ixp Chain A Binding Site BS01

Receptor Information

>2ixp Chain A (length=310) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SLDRVDWPHATFSTPVKRIFDTQTTLDFQSSLAIHRIKYHLHKYTTLISH
CSDPDPHATASSIAMVNGLMGVLDKLAHLIDETPPLGNLACREWHHKLDE
RLPQWLQEMLPSEYHEVVPELQYYLGNSFGSSTRLDYGTGHELSFMATVA
ALDMLGMFPHMRGADVFLLFNKYYTIMRRLILTYTLEPAGSHGVWGLDDH
FHLVYILGSSQWQLLDAQAPLQPREILDKSLVREYKDTNFYCQGINFINE
VKMGPFEEHSPILYDIAVTVPRWSKVCKGLLKMYSVEVLKKFPVVQHFWF
GTGFFPWVNI

Ligand information

>2ixp Chain F (length=6) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cAAPKc

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	2ixp Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	K298 F299 P300
Binding residue (residue number reindexed from 1)	K291 F292 P293

Enzymatic activity

Enzyme Commision number

5.2.1.8: peptidylprolyl isomerase.

Gene Ontology

	Molecular Function
GO:0019211	phosphatase activator activity

View graph for
Molecular Function

External links

PDB	RCSB:2ixp, PDBe:2ixp, PDBj:2ixp
PDBsum	2ixp
PubMed	16885030
UniProt	P40454\|PTPA1_YEAST Serine/threonine-protein phosphatase 2A activator 1 (Gene Name=RRD1)

[Back to BioLiP]