Structure of PDB 2if8 Chain A Binding Site BS01

Receptor Information
>2if8 Chain A (length=255) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLLIFKPAFPQELEFYKAIQGDAPLCSWMPTYLGVLNESKQYLVLENLLY
GFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKI
QKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNP
HLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWEL
LNDVDKLMRDDFIDSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIF
MKFLE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2if8 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2if8 Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		K133 D325
Binding residue
(residue number reindexed from 1)		K61 D223
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
2.7.1.151: inositol-polyphosphate multikinase.
Gene Ontology
Molecular Function
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824 inositol-1,4,5,6-tetrakisphosphate 3-kinase activity
GO:0000825 inositol-1,3,4,5-tetrakisphosphate 6-kinase activity
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030674 protein-macromolecule adaptor activity
GO:0046872 metal ion binding
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0047326 inositol-1,3,4,6-tetrakisphosphate 5-kinase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000821 regulation of arginine metabolic process
GO:0006525 arginine metabolic process
GO:0016236 macroautophagy
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0090575 RNA polymerase II transcription regulator complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2if8, PDBe:2if8, PDBj:2if8
PDBsum2if8
PubMed17050532
UniProtP07250|IPMK_YEAST Inositol polyphosphate multikinase (Gene Name=ARG82)

[Back to BioLiP]