Structure of PDB 2iew Chain A Binding Site BS01

Receptor Information
>2iew Chain A (length=258) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLLIFKPAFPQELEFYKAIQGDAPLCSWMPTYLGVLNESKQYLVLENLLY
GFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKI
QKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNP
HLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWEL
LNDVDKLMRDDFIDSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIF
MKFLEHHH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2iew Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2iew Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E271 N274
Binding residue
(residue number reindexed from 1)		E199 N202
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
2.7.1.151: inositol-polyphosphate multikinase.
Gene Ontology
Molecular Function
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824 inositol-1,4,5,6-tetrakisphosphate 3-kinase activity
GO:0000825 inositol-1,3,4,5-tetrakisphosphate 6-kinase activity
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030674 protein-macromolecule adaptor activity
GO:0046872 metal ion binding
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0047326 inositol-1,3,4,6-tetrakisphosphate 5-kinase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000821 regulation of arginine metabolic process
GO:0006525 arginine metabolic process
GO:0016236 macroautophagy
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0090575 RNA polymerase II transcription regulator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2iew, PDBe:2iew, PDBj:2iew
PDBsum2iew
PubMed17050532
UniProtP07250|IPMK_YEAST Inositol polyphosphate multikinase (Gene Name=ARG82)

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