Structure of PDB 2i6q Chain A Binding Site BS01

Receptor Information

>2i6q Chain A (length=503) Species: 9606 (Homo sapiens)

SKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVS
VAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAA
LNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHI
REILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDT
KALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETC
RGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISP
GFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLAL
RRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVV
SQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFF
QVGLVSWGLYNPCLRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNF
LPL

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 2i6q Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2i6q Structure of complement component c2a: implications for convertase formation and substrate binding.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): S242 S244 T317
• Binding residue (residue number reindexed from 1): S20 S22 T95
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H487 D541
• Catalytic site (residue number reindexed from 1): H265 D319
• Enzyme Commision number: 3.4.21.43: classical-complement-pathway C3/C5 convertase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0006956 complement activation

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:2i6q, PDBe:2i6q, PDBj:2i6q
• PDBsum: 2i6q
• PubMed: 17027507
• UniProt: P06681|CO2_HUMAN Complement C2 (Gene Name=C2)