Structure of PDB 2i6m Chain A Binding Site BS01

Receptor Information

>2i6m Chain A (length=161) Species: 2287 (Saccharolobus solfataricus)

MYWVRRKTIGGSGLPYTENEILEWRKEGVKRVLVLPEDWEIEESWGDKDY
YLSILKKNGLQPLHIPIPDGGVPSDSQFLTIMKWLLSEKEGNLVHCVGGI
GRTGTILASYLILTEGLEVESAIDEVRLVRPGAVQTYEQEMFLLRVEGMR
KSWLKNIYSNS

Ligand information

• Ligand ID: WO4
• InChI: InChI=1S/4O.W/q;;2*-1;
• InChIKey: PBYZMCDFOULPGH-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-][W](=O)(=O)[O-]
  ACDLabs 10.04
  CACTVS 3.341: [O-][W]([O-])(=O)=O
• Formula: O4 W
• Name: TUNGSTATE(VI)ION
• PDB chain: 2i6m Chain A Residue 1380

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2i6m Enzyme-substrate interactions revealed by the crystal structures of the archaeal Sulfolobus PTP-fold phosphatase and its phosphopeptide complexes
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D69 C96 V97 G98 I100 G101 R102
• Binding residue (residue number reindexed from 1): D69 C96 V97 G98 I100 G101 R102
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

Molecular Function

• GO:0004725 protein tyrosine phosphatase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006470 protein dephosphorylation
• GO:0016311 dephosphorylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2i6m, PDBe:2i6m, PDBj:2i6m
• PDBsum: 2i6m
• PubMed: 17173287
• UniProt: Q97VZ7