Structure of PDB 2i2x Chain A Binding Site BS01

Receptor Information
>2i2x Chain A (length=459) Species: 2208 (Methanosarcina barkeri) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKRYTSMAYANADEMTFGVSKYPVKAGLDLEIGAGYTIPEINYAPRPEAG
ASKEKLIKEYERITTDVMERMVQVGFPAIILETEHVQQMSNNPSWGAEVA
HAQKTIMEKYHDEYGIKCALRHTIGDIRENREFLQLRGDKYSVFLEAFEQ
CAENGADLLSVESMGGKEVFDYAVLRNDIPGLLYSIGCLGSIDMELIWTD
ISKIAKKTGTISAGDTDCAQANTAMFIGGGLLNKNLAHTIAVIARAISAP
RSLVAYEAGAVGPGKDCGYENIIVKAITGMPMTMEGKTSTCAHSDVMGNL
VMQCCDCWSNESVEYHGEFGGTTVQCWSETLAYDCALMNTALETKNDKVL
RDLMMLSDRYRDPQAYMLAYDNAYRVGQSIVKDGDNIYLRAKNAAIECCN
IIEEGAAGKLELSRFETKALADAKAALEALPDDMDKFMDDCLTKYKSEVK
VFKPENYGF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2i2x Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2i2x Insight into the mechanism of biological methanol activation based on the crystal structure of the methanol-cobalamin methyltransferase complex
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E164 C220 C269
Binding residue
(residue number reindexed from 1)		E162 C218 C267
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.90: methanol--corrinoid protein Co-methyltransferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
GO:0047152 methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity
Biological Process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2i2x, PDBe:2i2x, PDBj:2i2x
PDBsum2i2x
PubMed17142327
UniProtQ46EH3|MTAB_METBF Methanol--corrinoid protein co-methyltransferase (Gene Name=mtaB)

[Back to BioLiP]