Structure of PDB 2i0q Chain A Binding Site BS01

Receptor Information

>2i0q Chain A (length=461) Species: 200597 (Sterkiella nova)

KYEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLY
LKQQKGAGDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQR
QFNANVFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKN
EISILQNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVH
ELDEYTNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQ
KKVLILSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVV
LTEVDKKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVK
EWVKGYDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLY
TQDGLGANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNG
FYLIKDTKLIY

Ligand information

>2i0q Chain D (length=11)

gggttttgggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2i0q Structural reorganization and the cooperative binding of single-stranded telomere DNA in Sterkiella nova.
• Resolution: 1.91 Å
• Binding residue (original residue number in PDB): F63 Y65 K66 T67 Y72 S75 K77 F107 I112 Y130 Q135 D223 D225 Y239 L258 L260 K261 R274 S275 H292 Y293
• Binding residue (residue number reindexed from 1): F29 Y31 K32 T33 Y38 S41 K43 F73 I78 Y96 Q101 D189 D191 Y205 L224 L226 K227 R240 S241 H258 Y259

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0010521 telomerase inhibitor activity
• GO:0043047 single-stranded telomeric DNA binding
• GO:0098505 G-rich strand telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0016233 telomere capping
• GO:0032210 regulation of telomere maintenance via telomerase

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000782 telomere cap complex
• GO:0000783 nuclear telomere cap complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:2i0q, PDBe:2i0q, PDBj:2i0q
• PDBsum: 2i0q
• PubMed: 17082188
• UniProt: P29549|TEBA_STENO Telomere-binding protein subunit alpha (Gene Name=MAC-56A)