Structure of PDB 2hzp Chain A Binding Site BS01

Receptor Information
>2hzp Chain A (length=447) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLP
PVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVG
KRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKR
YKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDIL
EVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAV
GNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGW
FGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMK
ALRKKSVLLTGYLEYLIKHNYGKVVNIITPSHVEERGCQLTITFSVPNKD
VFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDS
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain2hzp Chain A Residue 544 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2hzp Crystal Structure of Homo sapiens Kynureninase.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		L137 T138 F165 D168 D250 A252 H253 Y275 K276
Binding residue
(residue number reindexed from 1)		L132 T133 F160 D163 D245 A247 H248 Y270 K271
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) F165 D250 Y275 K276 R434
Catalytic site (residue number reindexed from 1) F160 D245 Y270 K271 R421
Enzyme Commision number 3.7.1.3: kynureninase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0030170 pyridoxal phosphate binding
GO:0030429 kynureninase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006569 tryptophan catabolic process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019805 quinolinate biosynthetic process
GO:0034341 response to type II interferon
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0034516 response to vitamin B6
GO:0043420 anthranilate metabolic process
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hzp, PDBe:2hzp, PDBj:2hzp
PDBsum2hzp
PubMed17300176
UniProtQ16719|KYNU_HUMAN Kynureninase (Gene Name=KYNU)

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