Structure of PDB 2hzh Chain A Binding Site BS01

Receptor Information

>2hzh Chain A (length=499) Species: 230624 (Trametes ochracea)

AIGPSANLVVTNAAVAADGHSRDAVVVNGGTPGPLITGNKGDQFQLNVIN
NLTNFTMLKSTSVHWHGFFQKGTNWADGPAFVNQCPIAAGSSFLYDFSTP
IQAGTFWYHSHLSTQYCDGDRGPFVVYDPNDPSANLYDVDNLNTVITLTD
WYHTAAQNGPAKPGGADATLINGQGRGPSSPSADLAVISVTAGKRYRFRL
VSNSCDPNYTFSIDGHQMTIIQVDSINVQPLVVLKIQIYAAQRYSFILNA
NQAVNNYWIRANPNQGNVGFTNGINSAILRYSGAAATQPTTSQTSSVQPL
DQTNLHPLTATAVPGSPVAGGVNLAINQAFNFNGTNHFVDGASFVPPTVP
VLSQIVSGAQSAADLLASGLVYSLPSDANIEISFPATSAAAGGPHPFHLH
GHAFAVVRSAGSTTYNYNDPIFRDTVSTGTPAANDNVTIRFKTNNPGPWF
LHCHIDFHLEAGFAVVFAQDIPDVASANPTPNAWSDLCPVYDAASSSSQ

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 2hzh Chain A Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2hzh Crystal structure of laccase from Coriolus zonatus at 2.6 A resolution
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): H395 C453 H458
• Binding residue (residue number reindexed from 1): H395 C453 H458
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
• Catalytic site (residue number reindexed from 1): H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
• Enzyme Commision number: 1.10.3.2: laccase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:2hzh, PDBe:2hzh, PDBj:2hzh
• PDBsum: 2hzh
• UniProt: Q8TG94