Structure of PDB 2hxt Chain A Binding Site BS01

Receptor Information
>2hxt Chain A (length=434) Species: 340 (Xanthomonas campestris pv. campestris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTIIALETHDVRFPTSRELDGSDAMNPDPDYSAAYVVLRTDGAEDLAGYG
LVFTIGRGNDVQTAAVAALAEHVVGLSVDKVIADLGAFARRLTNDSQLRW
LGPEKGVMHMAIGAVINAAWDLAARAANKPLWRFIAELTPEQLVDTIDFR
YLSDALTRDEALAILRDAQPQRAARTATLIEQGYPAYTTSPGWLGYSDEK
LVRLAKEAVADGFRTIKLKVGANVQDDIRRCRLARAAIGPDIAMAVDANQ
RWDVGPAIDWMRQLAEFDIAWIEEPTSPDDVLGHAAIRQGITPVPVSTGE
HTQNRVVFKQLLQAGAVDLIQIDAARVGGVNENLAILLLAAKFGVRVFPH
AGGVGLCELVQHLAMADFVAITGKMEDRAIEFVDHLHQHFLDPVRIQHGR
YLAPEVPGFSAEMHPASIAEFSYPDGRFWVEDLA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2hxt Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2hxt Evolution of Enzymatic Activities in the Enolase Superfamily: l-Fuconate Dehydratase from Xanthomonas campestris.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		D248 E274 E301
Binding residue
(residue number reindexed from 1)		D247 E273 E300
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) T55 T190 K218 K220 D248 N250 E274 G300 E301 D324 P350 H351 A352 D368 K375 E382
Catalytic site (residue number reindexed from 1) T54 T189 K217 K219 D247 N249 E273 G299 E300 D323 P349 H350 A351 D367 K374 E381
Enzyme Commision number 4.2.1.68: L-fuconate dehydratase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
GO:0046872 metal ion binding
GO:0050023 L-fuconate dehydratase activity
Biological Process
GO:0016052 carbohydrate catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2hxt, PDBe:2hxt, PDBj:2hxt
PDBsum2hxt
PubMed17144652
UniProtQ8P3K2|FUCD_XANCP L-fuconate dehydratase (Gene Name=XCC4069)

[Back to BioLiP]