Structure of PDB 2hvy Chain A Binding Site BS01

Receptor Information
>2hvy Chain A (length=320) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RILPADIKREVLIKDENAETNPDWGFPPEKRPIEMHIQFGVINLDKPPGP
TSHEVVAWIKKILNLEKAGHGGTLDPKVSGVLPVALEKATRVVQALLPAG
KEYVALMHLHGDVPEDKIIQVMKEFEGEIIQRPPLLRTRKVYYIEVLEIE
GRDVLFRVGVEAGTYIRSLIHHIGLALGVGAHMSELRRTRSGPFKEDETL
ITLHDLVDYYYFWKEDGIEEYFRKAIQPMEKAVEHLPKVWIKDSAVAAVT
HGADLAVPGIAKLHAGIKRGDLVAIMTLKDELVALGKAMMTSQEMLEKTK
GIAVDVEKVFMPRDWYPKLW
Ligand information
>2hvy Chain E (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggguccgccuugagugcccgggugagaagcaugaucccggguaauuaugg
cggacccacag
<<<<<<<<<......<<<<<<<.............>>>>>>>......>>
>>>>>>>....
Receptor-Ligand Complex Structure
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PDB2hvy Crystal structure of an H/ACA box ribonucleoprotein particle
Resolution2.3 Å
Binding residue
(original residue number in PDB)		G59 H63 E64 H80 R101 L107 K259 S261 A262 A265 H268 G269 A270 A273 P275 G276 K317 G318 I319 K325 V326 R330 K335 W337
Binding residue
(residue number reindexed from 1)		G49 H53 E54 H70 R91 L97 K242 S244 A245 A248 H251 G252 A253 A256 P258 G259 K300 G301 I302 K308 V309 R313 K318 W320
Enzymatic activity
Enzyme Commision number 5.4.99.25: tRNA pseudouridine(55) synthase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0160148 tRNA pseudouridine(55) synthase activity
Biological Process
GO:0000495 box H/ACA sno(s)RNA 3'-end processing
GO:0001522 pseudouridine synthesis
GO:0006396 RNA processing
GO:0008033 tRNA processing
GO:0009451 RNA modification
GO:0031118 rRNA pseudouridine synthesis
GO:0031119 tRNA pseudouridine synthesis
GO:0031120 snRNA pseudouridine synthesis
GO:1990481 mRNA pseudouridine synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:2hvy, PDBe:2hvy, PDBj:2hvy
PDBsum2hvy
PubMed16943774
UniProtQ7LWY0|TRUB_PYRFU Probable tRNA pseudouridine synthase B (Gene Name=truB)

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