Structure of PDB 2hv6 Chain A Binding Site BS01

Receptor Information
>2hv6 Chain A (length=301) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVS
EAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVA
TVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGV
LRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFI
WGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEH
SNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVT
S
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2hv6 Chain A Residue 324 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2hv6 Structure and mechanism of the phosphotyrosyl phosphatase activator.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		G208 D214
Binding residue
(residue number reindexed from 1)		G187 D193
Annotation score1
Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005102 signaling receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008160 protein tyrosine phosphatase activator activity
GO:0019211 phosphatase activator activity
GO:0019888 protein phosphatase regulator activity
GO:0019902 phosphatase binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0007052 mitotic spindle organization
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0034704 calcium channel complex
GO:0070062 extracellular exosome
GO:1904949 ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hv6, PDBe:2hv6, PDBj:2hv6
PDBsum2hv6
PubMed16916641
UniProtQ15257|PTPA_HUMAN Serine/threonine-protein phosphatase 2A activator (Gene Name=PTPA)

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