Structure of PDB 2huo Chain A Binding Site BS01

Receptor Information
>2huo Chain A (length=258) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FRNYTSGPLLDRVFTTYKLMHTHQTVDFVSRKRIQYGSFSYKKMTIMEAV
GMLDDLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVGLLHDLGK
IMALWGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELG
MYQPHCGLENVLMSWGHDEYLYQMMKFNKFSLPSEAFYMIRFHSFYPWHT
GGDYRQLCSQQDLDMLPWVQEFNKFDLYTKCPDLPDVESLRPYYQGLIDK
YCPGTLSW
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain2huo Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2huo Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H98 H123 D124 D253
Binding residue
(residue number reindexed from 1)		H71 H96 D97 D226
Annotation score1
Enzymatic activity
Enzyme Commision number 1.13.99.1: inositol oxygenase.
Gene Ontology
Molecular Function
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0005506 iron ion binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0050113 inositol oxygenase activity
Biological Process
GO:0019310 inositol catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016234 inclusion body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2huo, PDBe:2huo, PDBj:2huo
PDBsum2huo
PubMed17012379
UniProtQ9QXN5|MIOX_MOUSE Inositol oxygenase (Gene Name=Miox)

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