Structure of PDB 2hqw Chain A Binding Site BS01

Receptor Information

QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMI
NEVDADGNGTIDFPEFLTMMARSEEEIREAFRVFDKDGNGYISAAELRHV
MTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT

Ligand information

KKKATFRAITSTLASSFKRRRS

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

PDB	2hqw The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	E11 F12 F19 M36 Q41 E47 D50 M51 E54 E84 E87 V91 F92 M109 L112 E120 E123 M124 E127 F141 M144 M145
Binding residue (residue number reindexed from 1)	E9 F10 F17 M34 Q39 E45 D48 M49 E52 E76 E79 V83 F84 M101 L104 E112 E115 M116 E119 F133 M136 M137

Enzymatic activity

Catalytic site (original residue number in PDB)	V35
Catalytic site (residue number reindexed from 1)	V33
Enzyme Commision number	?

Gene Ontology

	Molecular Function
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0010856	adenylate cyclase activator activity
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030235	nitric-oxide synthase regulator activity
GO:0031432	titin binding
GO:0031800	type 3 metabotropic glutamate receptor binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0044325	transmembrane transporter binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0050998	nitric-oxide synthase binding
GO:0072542	protein phosphatase activator activity

	Biological Process
GO:0000086	G2/M transition of mitotic cell cycle
GO:0001975	response to amphetamine
GO:0002027	regulation of heart rate
GO:0005513	detection of calcium ion
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016240	autophagosome membrane docking
GO:0032465	regulation of cytokinesis
GO:0035458	cellular response to interferon-beta
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT
GO:0051592	response to calcium ion
GO:0051649	establishment of localization in cell
GO:0055117	regulation of cardiac muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0071346	cellular response to type II interferon
GO:0090150	establishment of protein localization to membrane
GO:0090151	establishment of protein localization to mitochondrial membrane
GO:0098901	regulation of cardiac muscle cell action potential
GO:0140056	organelle localization by membrane tethering
GO:0140238	presynaptic endocytosis
GO:1900242	regulation of synaptic vesicle endocytosis
GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering
GO:2000300	regulation of synaptic vesicle exocytosis

	Cellular Component
GO:0000922	spindle pole
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005876	spindle microtubule
GO:0008076	voltage-gated potassium channel complex
GO:0030017	sarcomere
GO:0030426	growth cone
GO:0030672	synaptic vesicle membrane
GO:0031514	motile cilium
GO:0031966	mitochondrial membrane
GO:0032991	protein-containing complex
GO:0034704	calcium channel complex
GO:0043209	myelin sheath
GO:0044305	calyx of Held
GO:0097225	sperm midpiece
GO:0098685	Schaffer collateral - CA1 synapse
GO:0099523	presynaptic cytosol
GO:0099524	postsynaptic cytosol
GO:0150034	distal axon
GO:1902494	catalytic complex

External links

PDB	RCSB:2hqw, PDBe:2hqw, PDBj:2hqw
PDBsum	2hqw
PubMed	18073110
UniProt	P0DP29\|CALM1_RAT Calmodulin-1 (Gene Name=Calm1)