Structure of PDB 2hpm Chain A Binding Site BS01

Receptor Information
>2hpm Chain A (length=1143) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKFAHLHQHTQFSLLDGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRKRGGYFHLTLLAKDFTGYQNL
VRLASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRL
DLAEARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVA
TNDGHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRA
MLPEAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLGRTEAQYLR
ELTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELRKR
EWTAEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGS
AAGSLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRV
IQYVRERYGEDKVAQIGTFGSLASKAALKDVARVYGIPHKKAEELAKLIP
VQFGKPKPLQEAELRAEMEKDERIRQVIEVAMRLEGLNRHASVHAAGVVI
AAEPLTDLVPLMRDQEGRPVTQYDMGAVEALGLLKMDFLGLRTLTFLDEA
RRIVKESKGVELDYDRLPLDDPKTFELLSRGETKGVFQLESGGMTATVRG
LKPRRLEDIIALVSLYRPGPMEHIPTYIRRHHGQEPVSYAEFPHAEKYLR
PILDETYGIPVYQEQIMQIASQVAGYSLGEADLLRRAMGKKRVEEMQKHR
ERFVRGAKERGVPEEEANRLFDMLEAFANYGFNKSHAAAYSLLSYQTAYV
KAHYPVEFMAALLSVERHDSDKVAEYIRDARALGIPVLPPDVNRSGFDFK
VVGEEILFGLSAVKNVGEMAARAILEERERGGPFKSLGDFLKRLPEQVVN
KRALESLVKAGALDAFGDRARLLASLEPLLRWAAETRERGRSGLVGLFAE
VEEPPLVEASPLDEITMLRYEKEALGIYVSGHPVLRYPGLREVASCTIEE
LSEFVRELPGKPKVLLSGMVEEVRFTLSDETGALEVVKEDIPLLVLAEVE
RVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGARLKSLLDEHPGSLPVY
LRVLGPFGEALFALREVRVGEEALGLLEAEGYRAYLVPDREVF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2hpm Chain A Residue 1221 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2hpm The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		D20 H47 H214
Binding residue
(residue number reindexed from 1)		D16 H43 H205
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hpm, PDBe:2hpm, PDBj:2hpm
PDBsum2hpm
PubMed16959569
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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