Structure of PDB 2hma Chain A Binding Site BS01

Receptor Information

>2hma Chain A (length=364) Species: 1313 (Streptococcus pneumoniae)

SDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDCTATED
YKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNK
EIKFKAFLDYAITLGADYVATGHYARVARDEDGTVHMLRGVDNGKDQTYF
LSQLSQEQLQKTMFPLGHLEKPEVRRLAEEAGLSTAKKKDSTGICFIGEK
NFKNFLSNYLPAQPGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGDNAP
WFVVGKDLSKNILYVGQGFYHDSLMSTSLEASQVHFTREMPEEFTLECTA
KFRYRQPDSKVTVHVKGEKTEVIFAEPQRAITPGQAVVFYDGEECLGGGL
IDNAYRDGQVCQYI

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2hma Chain A Residue 374

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2hma The Crystal Structure of tRNA (5-Methylaminomethyl-2-Thiouridylate)-Methyltransferase TrmU from Streptococcus pneumoniae
• Resolution: 2.41 Å
• Binding residue (original residue number in PDB): G16 S19
• Binding residue (residue number reindexed from 1): G15 S18
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.8.1.13: tRNA-uridine 2-sulfurtransferase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0005524 ATP binding
• GO:0016740 transferase activity
• GO:0016783 sulfurtransferase activity
• GO:0103016 tRNA-uridine 2-sulfurtransferase activity

Biological Process

• GO:0002143 tRNA wobble position uridine thiolation
• GO:0006400 tRNA modification
• GO:0008033 tRNA processing

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2hma, PDBe:2hma, PDBj:2hma
• PDBsum: 2hma
• UniProt: Q97T38|MNMA_STRPN tRNA-specific 2-thiouridylase MnmA (Gene Name=mnmA)