Structure of PDB 2hhx Chain A Binding Site BS01

Receptor Information
>2hhx Chain A (length=574) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLR
PETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLA
AYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHL
VRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDT
KRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVL
GYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRPDTKKV
HTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDWLIFAA
DYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDEVTPNMR
RQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGVKRYMEN
IVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPIQGSAAD
IIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLCRLVPEVM
EQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
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PDB2hhx The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		T556 S557 A558 R578 K582 Y587 R615 Q624 N625 I626 P627 I628 R629 V828 H829 D830
Binding residue
(residue number reindexed from 1)		T254 S255 A256 R276 K280 Y285 R313 Q322 N323 I324 P325 I326 R327 V526 H527 D528
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2hhx, PDBe:2hhx, PDBj:2hhx
PDBsum2hhx
PubMed17179038
UniProtQ5KWC1

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