Structure of PDB 2hfz Chain A Binding Site BS01

Receptor Information
>2hfz Chain A (length=608) Species: 11077 (Kunjin virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDTSKIKNRIERLRREYSSTWHHDENHPYRTWNYHGSYEVKPTGSASSLV
NGVVRLLSKPWDTITNVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPEGVK
YVLNETTNWLWAFLAREKRPRMCSREEFIRKVNSNAEEQNQWRSAREAVE
DPKFWEMVDEEREAHLRGECHTCIYNMMGKGSRAIWFMWLGARFLEFEAL
GFLNEDHWLGRKNSGGGVEGLGLQKLGYILREVGTRPGGRIYADDTAGWD
TRITRADLENEAKVLELLDGEHRRLARAIIELTYRHKVVKVMRPAADGRT
VMDVISREDQRGSGQVVTYALNTFTNLAVQLVRMMEGEGVIGPDDVEKLT
KGKGPKVRTWLSENGEERLSRMAVSGDDCVVKPLDDRFATSLHFLNAMSK
VRKDIQEWKPSTGWYDWQQVPFCSNHFTELIMKDGRTLVTPCRGQDELVG
RARISPGAGWNVRDTACLAKSYAQMWLLLYFHRRDLRLMANAICSAVPVN
WVPTGRTTWSIHAGGEWMTTEDMLEVWNRVWIEENEWMEDKTPVEKWSDV
PYSGKREDIWCGSLIGTRARATWAENIQVAINQVRSIIGDEKYVDYMSSL
KRYEDTTL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2hfz Chain A Residue 906 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2hfz Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
Resolution3.0 Å
Binding residue
(original residue number in PDB)		A534 D536
Binding residue
(residue number reindexed from 1)		A243 D245
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2hfz, PDBe:2hfz, PDBj:2hfz
PDBsum2hfz
PubMed17287213
UniProtP14335|POLG_KUNJM Genome polyprotein

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