Structure of PDB 2hf4 Chain A Binding Site BS01

Receptor Information

>2hf4 Chain A (length=364) Species: 7227 (Drosophila melanogaster)

DEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRKDSYVGDEAQSK
RGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLN
PKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSH
TVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTEEREIVRD
IKEKLCYVALDFEQEMATAASSSSLEKSYELKDGQVITIGNERFRCPEAL
FQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIAD
RMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQE
YDESGPSIVHRKCF

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2hf4 Chain A Residue 902

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2hf4 Crystal Structures of Expressed Non-polymerizable Monomeric Actin in the ADP and ATP States.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): Q263 S265
• Binding residue (residue number reindexed from 1): Q252 S254
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0000281 mitotic cytokinesis
• GO:0006338 chromatin remodeling
• GO:0007291 sperm individualization
• GO:0030723 ovarian fusome organization
• GO:0032507 maintenance of protein location in cell
• GO:0035148 tube formation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0031011 Ino80 complex
• GO:0035060 brahma complex

External links

• PDB: RCSB:2hf4, PDBe:2hf4, PDBj:2hf4
• PDBsum: 2hf4
• PubMed: 16920713
• UniProt: P10987|ACT1_DROME Actin-5C (Gene Name=Act5C)