Structure of PDB 2hcb Chain A Binding Site BS01

Receptor Information

>2hcb Chain A (length=317) Species: 63363 (Aquifex aeolicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DFLNPKYTLENFIVGEGNRLAYEVVKEALENLGSLYNPIFIYGSVGTGKT
HLLQAAGNEAKKRGYRVIYSSADDFAQAMVEHLKKGTINEFRNMYKSVDL
LLLDDVQFLSGKERTQIEFFHIFNTLYLLEKQIILASDRHPQKLDGVSDR
LVSRFEGGILVEIELDNKTRFKIIKEKLKEFNLELRKEVIDYLLENTKNV
REIEGKIKLIKLKGFEGLERKERKERDKLMQIVEFVANYYAVKVEDILSD
KRRTSEARKIAMYLCRKVCSASLIEIARAFKDHTTVIHAIRSVEEEKKRK
FKHLVGFLEKQAFDKIC

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

2hcb Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2hcb Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling.
Resolution	3.51 Å
Binding residue (original residue number in PDB)	T126 D181
Binding residue (residue number reindexed from 1)	T50 D105
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003688	DNA replication origin binding
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006270	DNA replication initiation
GO:0006275	regulation of DNA replication

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Molecular Function

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Biological Process

External links

PDB	RCSB:2hcb, PDBe:2hcb, PDBj:2hcb
PDBsum	2hcb
PubMed	16829961
UniProt	O66659\|DNAA_AQUAE Chromosomal replication initiator protein DnaA (Gene Name=dnaA)

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