Structure of PDB 2hb5 Chain A Binding Site BS01

Receptor Information
>2hb5 Chain A (length=150) Species: 11801 (Moloney murine leukemia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HGTRPDLTDQPLPDADHTWYTDGSSLLQEGQRKAGAAVTTETEVIWAKAL
PAGTSAQRAELIALTQALKMAEGKKLNVYTDSRYAFATAHLTSEGKEIKN
KDEILALLKALFLPKRLSIIHCGHSAEARGNRMADQAARKAAITETPDTS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2hb5 Chain A Residue 200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2hb5 Crystal Structure of the Moloney Murine Leukemia Virus RNase H Domain.
Resolution1.59 Å
Binding residue
(original residue number in PDB)		D28 E66 D87
Binding residue
(residue number reindexed from 1)		D22 E60 D81
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2hb5, PDBe:2hb5, PDBj:2hb5
PDBsum2hb5
PubMed16912289
UniProtP03355|POL_MLVMS Gag-Pol polyprotein (Gene Name=gag-pol)

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