Structure of PDB 2hal Chain A Binding Site BS01

Receptor Information
>2hal Chain A (length=212) Species: 12092 (Hepatovirus A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STLEIAGLVRKNLVQFGVGEKNGSVRWVMNALGVKDDWLLVPSHAYKFEK
DYEMMEFYFNRGGTYYSISAGNVVIQSLDVGFQDVVLMKVPTIPKFRDIT
QHFIKKGDVPRALNRLATLVTTVNGTPMLISEGPLKMEEKATYVHKKNDG
TTVDLTVDQAWRGKGEGLPGMCGGALVSSNQSIQNAILGIHVAGGNSILV
AKLVTQEMFQNI
Ligand information
Receptor-Ligand Complex Structure
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PDB2hal An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors.
Resolution1.35 Å
Binding residue
(original residue number in PDB)		V144 H145 K146 G170 C172 A193 G194 G195 I198 V200
Binding residue
(residue number reindexed from 1)		V144 H145 K146 G170 C172 A193 G194 G195 I198 V200
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2hal, PDBe:2hal, PDBj:2hal
PDBsum2hal
PubMed16860823
UniProtP08617|POLG_HAVHM Genome polyprotein

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