Structure of PDB 2h9c Chain A Binding Site BS01

Receptor Information
>2h9c Chain A (length=88) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKTPEDCTGLADIREAIDRIDLDIVQALGRRMDYVKAASRFAPERVAAML
PERARWAEENGLDAPFVEGLFAQIIHWYIAEQIKYWRQ
Ligand information
Ligand IDNO3
InChIInChI=1S/NO3/c2-1(3)4/q-1
InChIKeyNHNBFGGVMKEFGY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-][N+]([O-])=O
OpenEye OEToolkits 1.5.0[N+](=O)([O-])[O-]
FormulaN O3
NameNITRATE ION
ChEMBLCHEMBL186200
DrugBankDB14049
ZINC
PDB chain2h9c Chain A Residue 100 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2h9c Two Crystal Structures of the Isochorismate Pyruvate Lyase from Pseudomonas aeruginosa.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		R31 R53 M57 I83 Y86
Binding residue
(residue number reindexed from 1)		R31 R45 M49 I75 Y78
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.99.21: isochorismate lyase.
5.4.99.5: chorismate mutase.
Gene Ontology
Molecular Function
GO:0004106 chorismate mutase activity
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0016853 isomerase activity
GO:0043904 isochorismate pyruvate lyase activity
Biological Process
GO:0009697 salicylic acid biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0042864 pyochelin biosynthetic process
GO:0046417 chorismate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2h9c, PDBe:2h9c, PDBj:2h9c
PDBsum2h9c
PubMed16914555
UniProtQ51507|PCHB_PSEAE Isochorismate pyruvate lyase (Gene Name=pchB)

[Back to BioLiP]