Structure of PDB 2h96 Chain A Binding Site BS01

Receptor Information
>2h96 Chain A (length=358) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKK
LSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYI
VMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN
IVVKSDCTLKILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENV
DLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV
RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA
SKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELI
YKEVMDLE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2h96 Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R127 Y130 V159 S161 D162 C163 W324 E329 E364
Binding residue
(residue number reindexed from 1)		R121 Y124 V153 S155 D156 C157 W318 E323 E358
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D145 K147 N150 D163 T182
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2h96, PDBe:2h96, PDBj:2h96
PDBsum2h96
PubMed16854050
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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