Structure of PDB 2h6m Chain A Binding Site BS01

Receptor Information
>2h6m Chain A (length=212) Species: 12092 (Hepatovirus A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STLEIAGLVRKNLVQFGVGEKNGSVRWVMNALGVKDDWLLVPSHAYKFEK
DYEMMEFYFNRGGTYYSISAGNVVIQSLDVGFQDVVLMKVPTIPKFRDIT
QHFIKKGDVPRALNRLATLVTTVNGTPMLISEGPLKMEEKATYVHKKNDG
TTVDLTVDQAWRGKGEGLPGMCGGALVSSNQSIQNAILGIHVAGGNSILV
AKLVTQEMFQNI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2h6m An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		H44 Y143 V144 H145 G167 G170 C172 H191 V192 A193 G194 I198 V200
Binding residue
(residue number reindexed from 1)		H44 Y143 V144 H145 G167 G170 C172 H191 V192 A193 G194 I198 V200
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2h6m, PDBe:2h6m, PDBj:2h6m
PDBsum2h6m
PubMed16860823
UniProtP08617|POLG_HAVHM Genome polyprotein

[Back to BioLiP]