Structure of PDB 2h5u Chain A Binding Site BS01

Receptor Information
>2h5u Chain A (length=499) Species: 259368 (Trametes maxima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVGPVADNTITNAATSPDGFSRQAVVVNGVTPGPLVAGNIGDRFQLNVID
NLTNHTMLKTTSVHWHGFFQQGTNWADGPAFINQCPISPGHSFLYDFQVP
NQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPHASRYDVDNDDTTITLAD
WYHTAAKLGPAFPNGADSTLINGKGRAPSDSSAQLSVVSVTKGKRYRFRL
VSLSCDPNFTFSIDGHNNTIIETDSVNSQPLNTDSIQIFAAQRYSFTLNA
NQAVDNYWIRANPNFGNVGFNGGINSAILRYDGAPAVEPTTNQSTSTQPL
NETNLHPLVSTPVPGSPAAGGVDKAINMAFNFNGSNFFINGASFTPPSVP
VLLQILSGAQTAQDLLPSGSVYTLPSNASIEISFPATAAAPGAPHPFHLH
GHVFAVVRSAGSTVYNYSNPIFRDVVSTGTPAAGDNVTIRFLTNNPGPWF
LHCHIDFHLEGGFAVVQAEDVPDVKATNPVPQAWSDLCPTYDANAPSDQ
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain2h5u Chain B Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2h5u Purification, crystallization and preliminary X-ray study of the fungal laccase from Cerrena maxima
Resolution1.9 Å
Binding residue
(original residue number in PDB)		F20 S21
Binding residue
(residue number reindexed from 1)		F20 S21
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
Catalytic site (residue number reindexed from 1) H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
Enzyme Commision number 1.10.3.2: laccase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0052716 hydroquinone:oxygen oxidoreductase activity
Biological Process
GO:0046274 lignin catabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h5u, PDBe:2h5u, PDBj:2h5u
PDBsum2h5u
PubMed17012782
UniProtD0VWU3|LAC1_TRAMX Laccase

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