Structure of PDB 2h5j Chain A Binding Site BS01

Receptor Information
>2h5j Chain A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKY
EVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP
VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIET
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2h5j Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R64 H121 C163
Binding residue
(residue number reindexed from 1)		R31 H88 C130
Enzymatic activity
Catalytic site (original residue number in PDB) T62 S63 H121 G122 C163 R164
Catalytic site (residue number reindexed from 1) T29 S30 H88 G89 C130 R131
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h5j, PDBe:2h5j, PDBj:2h5j
PDBsum2h5j
PubMed16781734
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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