Structure of PDB 2h54 Chain A Binding Site BS01

Receptor Information
>2h54 Chain A (length=170) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSSGSEGNVKLCSLEEAQRIWSAEIYPIMDKSSRTRLALIICNEEFDSIP
RRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTS
DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP
KVIIIQACRGDSPGVVWFKD
Ligand information
Receptor-Ligand Complex Structure
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PDB2h54 An allosteric circuit in caspase-1.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		R179 H237 C285
Binding residue
(residue number reindexed from 1)		R52 H110 C158
Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 R286
Catalytic site (residue number reindexed from 1) P50 R51 H110 G111 C158 R159
Enzyme Commision number 3.4.22.36: caspase-1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h54, PDBe:2h54, PDBj:2h54
PDBsum2h54
PubMed18590738
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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