Structure of PDB 2h4y Chain A Binding Site BS01

Receptor Information
>2h4y Chain A (length=163) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVKLCSLEEAQRIWSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEV
DITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVF
MSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQA
CKGDSPGVVWFKD
Ligand information
Receptor-Ligand Complex Structure
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PDB2h4y An allosteric circuit in caspase-1.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		R179 H237 Q283 C285
Binding residue
(residue number reindexed from 1)		R45 H103 Q149 C151
Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 K286
Catalytic site (residue number reindexed from 1) P43 R44 H103 G104 C151 K152
Enzyme Commision number 3.4.22.36: caspase-1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h4y, PDBe:2h4y, PDBj:2h4y
PDBsum2h4y
PubMed18590738
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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