Structure of PDB 2h4m Chain A Binding Site BS01

Receptor Information
>2h4m Chain A (length=827) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPDEQGLQQILQLLKESQSPDTTIQRTVQQKPDFNNYLIFVLTKLKSEDE
PTRSLSGLILKNNVKFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILI
TTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILD
SDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHID
SFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQR
TQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDID
IILLKTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVV
KESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLS
RYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACT
ELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQ
MLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCV
NLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLV
ARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPIL
GTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNT
PKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSA
FRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQ
VGDENWRRFSDQFPLPLKERLAAFYGV
Ligand information
>2h4m Chain C (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NNQSSNFGPMKGGNFGGRSSGPY
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2h4m Rules for nuclear localization sequence recognition by karyopherin beta 2.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		K377 A381 D384 W460 E498 S502 E509 I540 D543 T547 F584 D639 V643 Q685 N726 N727 W730 T766 E769 N770 I773 R777 N803 I804 R805 E809
Binding residue
(residue number reindexed from 1)		K314 A318 D321 W397 E435 S439 E446 I477 D480 T484 F521 D576 V580 Q622 N663 N664 W667 T703 E706 N707 I710 R714 N740 I741 R742 E746
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:2h4m, PDBe:2h4m, PDBj:2h4m
PDBsum2h4m
PubMed16901787
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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