Structure of PDB 2h2p Chain A Binding Site BS01

Receptor Information
>2h2p Chain A (length=444) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMG
ALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGAL
EDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIF
RLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIK
AVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFG
PIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGG
FNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTV
LGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMT
DNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAEQ
Ligand information
Ligand IDSEK
InChIInChI=1S/CHNSe/c2-1-3/h3H/p-1
InChIKeyCRDYSYOERSZTHZ-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(#N)[Se-]
ACDLabs 10.04
CACTVS 3.341		[Se-]C#N
FormulaC N Se
NameSELENOCYANATE ION
ChEMBL
DrugBank
ZINC
PDB chain2h2p Chain A Residue 466 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2h2p Uncoupling of a CLC Cl(-)/H(+) Exchange Transporter by Polyatomic Anions
Resolution3.1 Å
Binding residue
(original residue number in PDB)		G106 S107 F348 I448
Binding residue
(residue number reindexed from 1)		G90 S91 F332 I432
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0015297 antiporter activity
GO:0042802 identical protein binding
GO:0062158 chloride:proton antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990451 cellular stress response to acidic pH
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h2p, PDBe:2h2p, PDBj:2h2p
PDBsum2h2p
PubMed16905147
UniProtP37019|CLCA_ECOLI H(+)/Cl(-) exchange transporter ClcA (Gene Name=clcA)

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