Structure of PDB 2h0l Chain A Binding Site BS01

Receptor Information
>2h0l Chain A (length=316) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALRGTVTDFSGFDGEADAEVLRKAMEGLGTDEDSILNLLTARSNAQRQQI
AEEFETLFGRDLVNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGA
GTDEKVLTEIIASRTPEELRAIKQAYEEEYGSNLEDDVVGDTSGYYQEML
VVLLQANRDPDTAIDDAQVELDAQALFQAGELKWGTDEEEFITILGTRSV
SHLRRVFDKYMTISGFQIEETIDTSGNLENLLLAVVKSIRSIPAYLAETL
YYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTS
GDYKKALLLLSGGEDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2h0l Chain A Residue 1200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2h0l Identification of the Residues Involved in the Formation of Annexin V Trimers within 2D and 3D Crystals
Resolution2.59 Å
Binding residue
(original residue number in PDB)		M26 G28 L29 G30 E70
Binding residue
(residue number reindexed from 1)		M25 G27 L28 G29 E69
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
GO:0017046 peptide hormone binding
GO:0030971 receptor tyrosine kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0007596 blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0043065 positive regulation of apoptotic process
GO:0050819 negative regulation of coagulation
GO:0051592 response to calcium ion
GO:0070588 calcium ion transmembrane transport
GO:0071284 cellular response to lead ion
GO:0097066 response to thyroid hormone
GO:0097211 cellular response to gonadotropin-releasing hormone
GO:1901317 regulation of flagellated sperm motility
GO:1902721 negative regulation of prolactin secretion
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0009897 external side of plasma membrane
GO:0012506 vesicle membrane
GO:0014704 intercalated disc
GO:0030018 Z disc
GO:0030425 dendrite
GO:0030672 synaptic vesicle membrane
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0072563 endothelial microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h0l, PDBe:2h0l, PDBj:2h0l
PDBsum2h0l
PubMed
UniProtP14668|ANXA5_RAT Annexin A5 (Gene Name=Anxa5)

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