Structure of PDB 2h0j Chain A Binding Site BS01

Receptor Information
>2h0j Chain A (length=112) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVDVPLLAG
EELMSGEYVMEFHAGDYFASKNAADQPFLTIVTVRFQLADPDAHYHIPLL
LSPFGYQVYRGS
Ligand information
Ligand IDURN
InChIInChI=1S/C4H6N4O2/c5-1-2(6)7-4(10)8-3(1)9/h5H2,(H4,6,7,8,9,10)
InChIKeyBBTNLADSUVOPPN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C1NC(N)=C(N)C(=O)N1
CACTVS 3.341NC1=C(N)C(=O)NC(=O)N1
OpenEye OEToolkits 1.5.0C1(=C(NC(=O)NC1=O)N)N
FormulaC4 H6 N4 O2
Name5,6-DIAMINOPYRIMIDINE-2,4(1H,3H)-DIONE;
5,6-DIAMINOURACIL
ChEMBLCHEMBL34076
DrugBankDB03826
ZINCZINC000001666585
PDB chain2h0j Chain A Residue 122 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2h0j Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H14 R49 Y118
Binding residue
(residue number reindexed from 1)		H7 R42 Y109
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.2.17: hydroxyisourate hydrolase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0033971 hydroxyisourate hydrolase activity
GO:0042802 identical protein binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0019628 urate catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2h0j, PDBe:2h0j, PDBj:2h0j
PDBsum2h0j
PubMed16782815
UniProtO32142|HIUH_BACSU 5-hydroxyisourate hydrolase (Gene Name=pucM)

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