Structure of PDB 2gv2 Chain A Binding Site BS01

Receptor Information
>2gv2 Chain A (length=88) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2gv2 Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		L54 G58 Q59 I61 M62 Q72 H73 V93 H96 Y100
Binding residue
(residue number reindexed from 1)		L30 G34 Q35 I37 M38 Q48 H49 V69 H72 Y76
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:2gv2, PDBe:2gv2, PDBj:2gv2
PDBsum2gv2
PubMed16925398
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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