Structure of PDB 2ggz Chain A Binding Site BS01

Receptor Information
>2ggz Chain A (length=165) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGF
VDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQ
ALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYK
SFDFSNVLRVICNGK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2ggz Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ggz The Crystal Structure of GCAP3 Suggests Molecular Mechanism of GCAP-linked Cone Dystrophies.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D64 N66 D68 F70 E75
Binding residue
(residue number reindexed from 1)		D44 N46 D48 F50 E55
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008048 calcium sensitive guanylate cyclase activator activity
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0007601 visual perception
Cellular Component
GO:0097381 photoreceptor disc membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ggz, PDBe:2ggz, PDBj:2ggz
PDBsum2ggz
PubMed16626734
UniProtO95843|GUC1C_HUMAN Guanylyl cyclase-activating protein 3 (Gene Name=GUCA1C)

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