Structure of PDB 2ge5 Chain A Binding Site BS01

Receptor Information
>2ge5 Chain A (length=219) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLRSDLINALYDENQKYDVCGIISAEGKIYPLGSDTKVLSTIFELFSRPI
INKIAEKHGYIVEEPKQQNHYPDFTLYKPSEPNKKIAIDIKTTYTNKENE
KIKFTLGGYTSFIRNNTKNIVYPFDQYIAHWIIGYVYTRVATRKSSLKTY
NINELNEIPKPYKGVKVFLQDKWVIAGDLAGSGNTTNIGSIHAHYKDFVE
GKGIFDSEDEFLDYWRNYE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2ge5 Positively Charged C-Terminal Subdomains of EcoRV Endonuclease: Contributions to DNA Binding, Bending, and Cleavage.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		T37 N70 D90 K92 T93 T94 Y95 G109 T111 S112 K119 G182 S183 T186
Binding residue
(residue number reindexed from 1)		T36 N69 D89 K91 T92 T93 Y94 G108 T110 S111 K118 G181 S182 T185
Binding affinityPDBbind-CN: Kd=381nM
Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2ge5, PDBe:2ge5, PDBj:2ge5
PDBsum2ge5
PubMed16981705
UniProtP04390|T2E5_ECOLX Type II restriction enzyme EcoRV (Gene Name=ecoRVR)

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