Structure of PDB 2g80 Chain A Binding Site BS01

Receptor Information

>2g80 Chain A (length=225) Species: 4932 (Saccharomyces cerevisiae)

DNYSTYLLDIEGTVCPISFVKETLFPYFTNKVPQLVQQDTRDSPVSNILS
QFHIDNKEQLQAHILELVAKDVKDPILKQLQGYVWAHGYESGQIKAPVYA
DAIDFIKRKKRVFIYSSGSVKAQKLLFGYVQDPNAPAHDSLDLNSYIDGY
FDINTSGKKTETQSYANILRDIGAKASEVLFLSDNPLELDAAAGVGIATG
LASRPGNAPVPDGQKYQVYKNFETL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2g80 Chain A Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2g80 Crystal structure of UTR4 protein (Unknown transcript 4 protein) (yel038w) from Saccharomyces cerevisiae at 2.28 A resolution
• Resolution: 2.28 Å
• Binding residue (original residue number in PDB): D25 E27 D200
• Binding residue (residue number reindexed from 1): D9 E11 D184
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.77: acireductone synthase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0016787 hydrolase activity
• GO:0043715 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
• GO:0043716 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
• GO:0043874 acireductone synthase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009086 methionine biosynthetic process
• GO:0019284 L-methionine salvage from S-adenosylmethionine
• GO:0019509 L-methionine salvage from methylthioadenosine

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:2g80, PDBe:2g80, PDBj:2g80
• PDBsum: 2g80
• UniProt: P32626|ENOPH_YEAST Enolase-phosphatase E1 (Gene Name=UTR4)