Structure of PDB 2g64 Chain A Binding Site BS01

Receptor Information
>2g64 Chain A (length=140) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFRMPIVTMERVDSFSAAHRLHSEKLSDAENKETFGKCNNSNGHGHNYVW
KVKLRGEVDPTSGMVYDLAKLKKEMSLVLDTVDHRNLDKDVEFFKTTVST
SENVAIYMFEKLKSVMSNPSVLYKVTIEETPKNIFTYKGS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2g64 Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2g64 Crystal Structure of Caenorhabditis Elegans 6-Pyruvoyl Tetrahydropterin Synthase
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H19 H44 H46
Binding residue
(residue number reindexed from 1)		H19 H44 H46
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H19 C38 H44 H46 D83 H84 E129
Catalytic site (residue number reindexed from 1) H19 C38 H44 H46 D83 H84 E129
Enzyme Commision number 4.2.3.12: 6-pyruvoyltetrahydropterin synthase.
Gene Ontology
Molecular Function
GO:0003874 6-pyruvoyltetrahydropterin synthase activity
GO:0016829 lyase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
Cellular Component
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2g64, PDBe:2g64, PDBj:2g64
PDBsum2g64
PubMed
UniProtO02058|PTPS_CAEEL Putative 6-pyruvoyl tetrahydrobiopterin synthase (Gene Name=ptps-1)

[Back to BioLiP]