Structure of PDB 2g2i Chain A Binding Site BS01
Receptor Information
>2g2i Chain A (length=271) Species:
9606
(Homo sapiens) [
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SPNYDKWEMERTDITMKHKLGGGEVYEGVWKKYSLTVAVKTLKEDTMEVE
EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECN
RQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVAD
FGLSRLMTGDTYTAPAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWE
IATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS
DRPSFAEIHQAFETMFQESSI
Ligand information
>2g2i Chain C (length=8) [
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EEIFGEFE
Receptor-Ligand Complex Structure
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PDB
2g2i
A SRC-like inactive conformation in the abl tyrosine kinase domain.
Resolution
3.12 Å
Binding residue
(original residue number in PDB)
K400 F401 P402 L445
Binding residue
(residue number reindexed from 1)
K169 F170 P171 L214
Enzymatic activity
Catalytic site (original residue number in PDB)
D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1)
D132 A134 R136 N137 D150 P171
Enzyme Commision number
2.7.10.2
: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672
protein kinase activity
GO:0004713
protein tyrosine kinase activity
GO:0005524
ATP binding
Biological Process
GO:0006468
protein phosphorylation
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Molecular Function
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Biological Process
External links
PDB
RCSB:2g2i
,
PDBe:2g2i
,
PDBj:2g2i
PDBsum
2g2i
PubMed
16640460
UniProt
P00519
|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)
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