Structure of PDB 2fya Chain A Binding Site BS01

Receptor Information

>2fya Chain A (length=272) Species: 9606 (Homo sapiens)

GRGSASLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPR
DCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDT
IFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHIS
VAMDKFGFSLPYVQYFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNR
LVFRGMSISRPNAVVGTTRHIRHSRNPQRFDRIAHTKETMLSDGLNSLTY
QVLDVQRYPLYTQITVDIGTPS

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 2fya Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2fya Structural Snapshots of beta-1,4-Galactosyltransferase-I Along the Kinetic Pathway.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D250 H340
• Binding residue (residue number reindexed from 1): D130 H220
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D248 D250 W310 E313 D314 H340 H343 R345
• Catalytic site (residue number reindexed from 1): D128 D130 W190 E193 D194 H220 H223 R225
• Enzyme Commision number: 2.4.1.-
  2.4.1.22: lactose synthase.
  2.4.1.275: neolactotriaosylceramide beta-1,4-galactosyltransferase.
  2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase.
  2.4.1.90: N-acetyllactosamine synthase.

Gene Ontology

Molecular Function

• GO:0016757 glycosyltransferase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:2fya, PDBe:2fya, PDBj:2fya
• PDBsum: 2fya
• PubMed: 16497331
• UniProt: P15291|B4GT1_HUMAN Beta-1,4-galactosyltransferase 1 (Gene Name=B4GALT1)