Structure of PDB 2fxf Chain A Binding Site BS01

Receptor Information

>2fxf Chain A (length=164) Species: 9606 (Homo sapiens)

KFVIRPATAADCSDILRLIKELAKYEYMEEQVILTEKDLLEDGFGEHPFY
HCLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRG
FGIGSEILKNLSQVAMRCRCSSMHFLVAEWNEPSINFYKRRGASDLWRLF
KIDKEYLLKMATEE

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2fxf Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2fxf The Crystal Structure of Human spermidine/spermine N1-acetyltransferase
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): E92 D93
• Binding residue (residue number reindexed from 1): E90 D91
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.57: diamine N-acetyltransferase.

Gene Ontology

Molecular Function

• GO:0004145 diamine N-acetyltransferase activity
• GO:0005515 protein binding
• GO:0008080 N-acetyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0019809 spermidine binding
• GO:0042802 identical protein binding

Biological Process

• GO:0001525 angiogenesis
• GO:0006596 polyamine biosynthetic process
• GO:0009447 putrescine catabolic process
• GO:0032918 spermidine acetylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2fxf, PDBe:2fxf, PDBj:2fxf
• PDBsum: 2fxf
• UniProt: P21673|SAT1_HUMAN Diamine acetyltransferase 1 (Gene Name=SAT1)