Structure of PDB 2fws Chain A Binding Site BS01

Receptor Information
>2fws Chain A (length=139) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS
DYEFTEGTVVFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEAS
EDGILEANHVSALACLGSPSTATVTIFDDDHAGIFTFEE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2fws Chain A Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2fws Ca(2+) regulation in the na(+)/ca(2+) exchanger involves two markedly different ca(2+) sensors
ResolutionN/A
Binding residue
(original residue number in PDB)		E385 D448 E451 D498 D500
Binding residue
(residue number reindexed from 1)		E15 D78 E81 D128 D130
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007154 cell communication
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:2fws, PDBe:2fws, PDBj:2fws
PDBsum2fws
PubMed16600866
UniProtP23685|NAC1_CANLF Sodium/calcium exchanger 1 (Gene Name=SLC8A1)

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