Structure of PDB 2ftw Chain A Binding Site BS01

Receptor Information
>2ftw Chain A (length=484) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGTILIKNGTVVNDDRYFKSDVLVENGIIKEISKNIEPKEGIKVVDATDK
LLLPGGIDTHTHFQLPFMGTVSVDDFDIGTQAAVAGGTTFIIDFVIPTRG
QSLLEAYDQWKKWADEKVNCDYSLHVAITWWSEQVSREMEILVKERGVNS
FKCFMAYKNSFMVTDQEMYHIFKRCKELGAIAQVHAENGDMVFEGQKKML
EMGITGPEGHELSRPEALEAEATNRAIVIADSVCTPVYIVHVQSIGAADV
ICKHRKEGVRVYGEPIAAGLGVDGSHMWNHDWRHAAAFVMGPPIRPDPRT
KGVLMDYLARGDLDCVGTDNCTFCADQKAMGKDDFTKIPNGVNGVEDRMS
IVWENGVNTGKLTWCQFVRATSSERARIFNIYPRKGRIDVGCDGDIVIWD
PNQSKTISKDTHHHAVDFNIFEGIKVTGIAVTTIVAGNIVWSDNKLSCVK
GSGRFVPRPPFGPVFDGIEQRDKVRNELLRKVDR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2ftw Chain A Residue 522 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ftw The Crystal Structures of Dihydropyrimidinases Reaffirm the Close Relationship between Cyclic Amidohydrolases and Explain Their Substrate Specificity.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		H66 H68 K158 D325
Binding residue
(residue number reindexed from 1)		H60 H62 K152 D319
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.2.2: dihydropyrimidinase.
Gene Ontology
Molecular Function
GO:0004157 dihydropyrimidinase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Biological Process
GO:0006208 pyrimidine nucleobase catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ftw, PDBe:2ftw, PDBj:2ftw
PDBsum2ftw
PubMed16517602
UniProtQ55DL0|DPYS_DICDI Dihydropyrimidinase (Gene Name=pyd2)

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