Structure of PDB 2fpx Chain A Binding Site BS01

Receptor Information
>2fpx Chain A (length=156) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQKYLFIDRDGTLISEPDFQVDRFDKLAFEPGVIPQLLKLQKAGYKLVMI
TNQDGLGTQSFPQADFDGPHNLMMQIFTSQGVQFDEVLICPHLPADECDC
RKPKVKLVERYLMDRANSYVIGDRATDIQLAENMGINGLRYDRETLNWPM
IGEQLT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2fpx Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2fpx Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C94 H96 C102 C104
Binding residue
(residue number reindexed from 1)		C90 H92 C98 C100
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.15: histidinol-phosphatase.
4.2.1.19: imidazoleglycerol-phosphate dehydratase.
Gene Ontology
Molecular Function
GO:0004401 histidinol-phosphatase activity
GO:0004424 imidazoleglycerol-phosphate dehydratase activity
GO:0016791 phosphatase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fpx, PDBe:2fpx, PDBj:2fpx
PDBsum2fpx
PubMed16966333
UniProtQ9S5G5|HIS7_ECO57 Histidine biosynthesis bifunctional protein HisB (Gene Name=hisB)

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