Structure of PDB 2fps Chain A Binding Site BS01

Receptor Information

>2fps Chain A (length=158) Species: 83334 (Escherichia coli O157:H7)

SQKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPGVIPQLLKLQKAGYKLV
MITNQDGLGTQSFPQADFDGPHNLMMQIFTSQGVQFDEVLICPHLPADEC
DCRKPKVKLVERYLMDRANSYVIGDRATDIQLAENMGINGLRYDRETLNW
PMIGEQLT

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 2fps Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2fps Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): C94 H96 C102 C104
• Binding residue (residue number reindexed from 1): C92 H94 C100 C102
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.15: histidinol-phosphatase.
  4.2.1.19: imidazoleglycerol-phosphate dehydratase.

Gene Ontology

Molecular Function

• GO:0004401 histidinol-phosphatase activity
• GO:0004424 imidazoleglycerol-phosphate dehydratase activity
• GO:0016791 phosphatase activity

Biological Process

• GO:0000105 L-histidine biosynthetic process
• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2fps, PDBe:2fps, PDBj:2fps
• PDBsum: 2fps
• PubMed: 16966333
• UniProt: Q9S5G5|HIS7_ECO57 Histidine biosynthesis bifunctional protein HisB (Gene Name=hisB)