Structure of PDB 2fpg Chain A Binding Site BS01

Receptor Information

>2fpg Chain A (length=305) Species: 9823 (Sus scrofa)

SYTASRKHLYVDKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGTTPGKG
GKTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAIDAEVPLVV
CITEGIPQQDMVRVKHRLLRQGKTRLIGPNCPGVINPGECKIGIMPGHIH
KKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFTDCLE
IFLNDPATEGIILIGEIGGNAEENAAEFLKQHNSGPKSKPVVSFIAGLTA
PPGRRMGHAGAIIAGGKGGAKEKITALQSAGVVVSMSPAQLGTTIYKEFE
KRKML

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 2fpg Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2fpg Interactions of GTP with the ATP-grasp Domain of GTP-specific Succinyl-CoA Synthetase
• Resolution: 2.96 Å
• Binding residue (original residue number in PDB): S162 G163 T164 H259
• Binding residue (residue number reindexed from 1): S161 G162 T163 H258
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E217 H259
• Catalytic site (residue number reindexed from 1): E216 H258
• Enzyme Commision number: 6.2.1.4: succinate--CoA ligase (GDP-forming).
  6.2.1.5: succinate--CoA ligase (ADP-forming).

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity

External links

• PDB: RCSB:2fpg, PDBe:2fpg, PDBj:2fpg
• PDBsum: 2fpg
• PubMed: 16481318
• UniProt: O19069|SUCA_PIG Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (Gene Name=SUCLG1)