Structure of PDB 2fln Chain A Binding Site BS01

Receptor Information
>2fln Chain A (length=366) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYGRESRQCPIPSHVIQVMTPMVDILMK
LFRNMTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB2fln An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Q59 Y61 L62 E97 L99 R103 P299 Q300 S301 S303 E304 E305 S307 R347
Binding residue
(residue number reindexed from 1)		Q34 Y36 L37 E72 L74 R78 P274 Q275 S276 S278 E279 E280 S282 R322
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2fln, PDBe:2fln, PDBj:2fln
PDBsum2fln
PubMed16615915
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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