Structure of PDB 2ffu Chain A Binding Site BS01

Receptor Information

>2ffu Chain A (length=494) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHD
QCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILV
DDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLD
SHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGF
DWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKY
DMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSG
TVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCK
PFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECH
NAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQ
IEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLN

Ligand information

>2ffu Chain P (length=9) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

STTPAPTTK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2ffu Dynamic Association between the Catalytic and Lectin Domains of Human UDP-GalNAc:Polypeptide {alpha}-N-Acetylgalactosaminyltransferase-2
Resolution	1.64 Å
Binding residue (original residue number in PDB)	V264 G265 A266 S267 F280 W282 W331 F361 R362 Q364 H365
Binding residue (residue number reindexed from 1)	V190 G191 A192 S193 F206 W208 W257 F287 R288 Q290 H291

Enzymatic activity

Enzyme Commision number

2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.

External links

PDB	RCSB:2ffu, PDBe:2ffu, PDBj:2ffu
PDBsum	2ffu
PubMed	16434399
UniProt	Q10471\|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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