Structure of PDB 2ff4 Chain A Binding Site BS01

Receptor Information

>2ff4 Chain A (length=379) Species: 83332 (Mycobacterium tuberculosis H37Rv)

EKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRNRPVGVDALIT
ALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLSIPD
NTCDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQ
FVEPFATALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPL
WTQLITAYYLSDRQSDALGAYRRVKTTLADDLGIDPGPTLRALNERILRQ
QPLDAKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRGYPLQAAA
TRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERI
RSAVTLNDGDHIRICDHEFTFQISAGTHG

Ligand information

>2ff4 Chain E (length=8) Species: 559292 (Saccharomyces cerevisiae S288C)

SLEVTEAD

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ff4 Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): R312 L313 A323 N324 V325 S326 R327 N348
• Binding residue (residue number reindexed from 1): R305 L306 A316 N317 V318 S319 R320 N341

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003924 GTPase activity
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0000160 phosphorelay signal transduction system
• GO:0006355 regulation of DNA-templated transcription

Cellular Component

• GO:0005886 plasma membrane
• GO:0009274 peptidoglycan-based cell wall

External links

• PDB: RCSB:2ff4, PDBe:2ff4, PDBj:2ff4
• PDBsum: 2ff4
• PubMed: 16477027
• UniProt: P9WGJ9|EMBR_MYCTU Transcriptional regulatory protein EmbR (Gene Name=embR)