Structure of PDB 2fai Chain A Binding Site BS01
Receptor Information
>2fai Chain A (length=236) Species:
9606
(Homo sapiens) [
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SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
Ligand information
>2fai Chain C (length=10) Species:
9606
(Homo sapiens) [
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HKILHRLLQD
Receptor-Ligand Complex Structure
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PDB
2fai
Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
I358 K362 L372 V376 E542
Binding residue
(residue number reindexed from 1)
I54 K58 L68 V72 E230
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:2fai
,
PDBe:2fai
,
PDBj:2fai
PDBsum
2fai
PubMed
16648639
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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